Ib lub ntiaj teb ib sib ntaus
─ Kev koom tes thoob ntiaj teb los tsim lub zej zog thoob ntiaj teb ntawm txoj hmoo zoo teb rau COVID-19 kev sib kis kis thoob qhov txhia chaw
Tus kab mob coronavirus tshiab cheb thoob plaws ntiaj teb tau ua rau muaj kev kub ntxhov thoob ntiaj teb COVID-19.Tus kab mob coronavirus tshiab tsis muaj ciam teb, tsis muaj lub tebchaws yuav dim ntawm qhov kev sib ntaus sib tua tiv thaiv COVID-19.Hauv kev teb rau qhov kev sib kis thoob ntiaj teb no COVID-19, Liming Bio-Products Corp tau koom tes los txhawb kev noj qab haus huv ntawm peb cov zej zog thoob ntiaj teb.
Peb lub ntiaj teb tam sim no tab tom ntsib kev cuam tshuam tsis tau pom dua los ntawm tus kab mob tshiab coronavirus 2019 (COVID-19) kis thoob qhov txhia chaw.Txog niaj hnub no, tsis muaj cov tshuaj muaj txiaj ntsig zoo rau kev kho tus kab mob no.Txawm li cas los xij, ntau qhov kev kuaj mob tau tsim los kuaj pom tus kab mob COVID-19.Cov kev ntsuam xyuas no yog ua raws li cov txheej txheem molecular lossis serological txhawm rau kuaj pom tus kabmob tshiab tus kabmob coronavirus tshwj xeeb nucleic acid lossis antibody biomarkers.Raws li COVID-19 tau mus txog qhov xwm txheej kis thoob ntiaj teb, kev kuaj mob ntxov ntawm tus kabmob tshiab tus kabmob tshiab yog qhov tseem ceeb hauv kev ntsuas kev kis tus kabmob thiab muaj nws, tab sis qhov kev sim zoo tshaj plaws rau kev siv thoob ntiaj teb tseem tsis tau muaj.Peb yuav tsum paub tias qhov kev ntsuam xyuas twg tuaj yeem siv rau kev tshuaj ntsuam xyuas, kuaj mob, thiab saib xyuas tus kab mob COVID-19, thiab lawv cov kev txwv yog dab tsi.Nws yog ib qho tseem ceeb heev yuav ua li cas kom siv tau zoo ntawm cov cuab yeej tshawb fawb no thiab pab txheeb xyuas thiab tswj qhov tshwm sim ntawm qhov kev sib kis sai sai thiab mob hnyav.
Lub hom phiaj ntawm kev kuaj pom tus kabmob tshiab no yog txhawm rau txiav txim siab seb tus neeg twg muaj tus kabmob COVID-19 lossis tus kabmob asymptotic uas tuaj yeem kis tus kabmob ntsiag to, muab cov ntaub ntawv tseem ceeb los coj kev txiav txim siab rau kev kho mob.Cov kev tshawb fawb yav dhau los tau pom tias 70% ntawm kev txiav txim siab kho mob nyob ntawm qhov kev sim.Thaum siv txoj kev tshawb nrhiav sib txawv, qhov yuav tsum tau muaj ntawm cov khoom siv tshawb nrhiav reagent kuj txawv.
Daim duab 1
Daim duab 1:Daim duab qhia txog cov theem tseem ceeb ntawm cov qib biomarker dav dav thaum lub sij hawm ib txwm muaj ntawm tus kab mob COVID-19.X-axis qhia txog pes tsawg hnub ntawm kev kis tus kab mob, thiab Y-axis qhia txog kev kis tus kab mob, kev sib xyaw ntawm cov tshuaj tiv thaiv kab mob, thiab cov tshuaj tiv thaiv kab mob hauv lub sijhawm sib txawv.Antibody hais txog IgM thiab IgG cov tshuaj tiv thaiv.Ob leeg RT-PCR thiab antigen detection yog siv los kuaj pom muaj lossis tsis muaj tus kabmob tshiab, uas yog pov thawj ncaj qha rau kev kuaj pom tus neeg mob thaum ntxov.Hauv ib lub lim tiam ntawm kev kis tus kab mob, kev kuaj xyuas PCR, lossis kev kuaj pom antigen yog nyiam.Tom qab tus kab mob tshiab coronavirus tau ntev txog li 7 hnub, IgM tshuaj tiv thaiv kab mob tiv thaiv tus kabmob tshiab tau maj mam nce hauv tus neeg mob cov ntshav, tab sis lub sijhawm ntawm kev muaj nyob yog luv, thiab nws cov concentration txo sai.Hauv qhov sib piv, IgG cov tshuaj tiv thaiv kab mob tawm tsam tus kab mob tshwm sim tom qab, feem ntau yog li 14 hnub tom qab kis tus kab mob.Lub IgG concentration maj mam nce, thiab nws tseem nyob ntev hauv cov ntshav.Yog li, yog tias IgM raug kuaj pom hauv tus neeg mob cov ntshav, nws txhais tau hais tias tus kab mob no tau kis tsis ntev los no, uas yog tus cim kab mob ntxov.Thaum kuaj pom cov tshuaj tiv thaiv IgG hauv tus neeg mob cov ntshav, nws txhais tau hais tias tus kab mob kis tau rau qee lub sijhawm.Nws tseem hu ua kab mob lig lossis kab mob yav dhau los.Nws feem ntau pom nyob rau hauv cov neeg mob uas nyob rau theem rov zoo.
Cov biomarkers ntawm tus mob coronavirus tshiab
Tus kab mob coronavirus tshiab yog tus kab mob RNA, uas muaj cov proteins thiab nucleic acids.Tus kab mob no invades tus tswv tsev (tib neeg) lub cev, nkag mus rau hauv cov hlwb los ntawm kev khi qhov chaw sib txuas receptor ACE2, thiab rov ua dua hauv cov tswv tsev, ua rau tib neeg lub cev tiv thaiv kab mob los teb rau cov neeg txawv teb chaws invaders thiab tsim cov tshuaj tiv thaiv tshwj xeeb.Yog li ntawd, cov vial nucleic acids thiab antigens, thiab cov tshuaj tiv thaiv tshwj xeeb tiv thaiv tus kabmob tshiab tuaj yeem siv tau los ua cov cim tshwj xeeb rau kev kuaj pom tus kabmob tshiab.Rau kev tshawb nrhiav nucleic acid, RT-PCR thev naus laus zis yog siv ntau tshaj plaws, thaum cov txheej txheem serological feem ntau siv rau kev kuaj pom tus kab mob tshiab tus kab mob coronavirus tshwj xeeb.Tam sim no, muaj ntau ntau txoj hauv kev uas peb tuaj yeem xaiv los kuaj tus kab mob COVID-19 [1].
Cov hauv paus ntsiab lus ntawm cov kev sim tseem ceeb rau cov kab mob coronavirus tshiab
Ntau qhov kev kuaj mob rau COVID_19 muaj nyob rau tam sim no, nrog ntau cov khoom siv kuaj tau txais kev pom zoo raws li kev tso cai siv thaum muaj xwm txheej ceev txhua hnub.Txawm hais tias qhov kev sim tshiab tsim tawm los nrog ntau lub npe sib txawv thiab cov qauv, txhua qhov kev sim COVID_19 tam sim no yeej vam khom ob lub thev naus laus zis loj: nucleic acid kuaj pom tus kab mob RNA thiab serological immunoassays uas kuaj pom cov kab mob tshwj xeeb (IgM thiab IgG).
01. Kev tshawb nrhiav Nucleic acid
Rov qab transcription-polymerase saw cov tshuaj tiv thaiv (RT-PCR), voj-mediated isothermal amplification (LAMP), thiab tiam tom ntej sequencing (NGS) yog cov txheej txheem nucleic acid rau kev kuaj pom tus kabmob tshiab RNA.RT-PCR yog thawj hom kev sim rau COVID-19, pom zoo los ntawm World Health Organization (WHO) thiab US Center for Disease Control and Prevention (CDC).
02.Serological antibody kuaj pom
Antibody yog ib qho kev tiv thaiv protein uas tsim tawm hauv tib neeg lub cev los teb rau tus kab mob.IgM yog hom tshuaj tiv thaiv ntxov thaum IgG yog hom tshuaj tiv thaiv tom qab.Cov ntshav ntshav los yog cov ntshav plasma feem ntau yog kuaj xyuas seb puas muaj cov IgM thiab IgG tshwj xeeb ntawm cov tshuaj tiv thaiv kab mob rau kev soj ntsuam cov theem mob hnyav thiab kev rov qab los ntawm COVID-19.Cov txheej txheem tshuaj tiv thaiv kab mob no suav nrog colloidal kub immunochromatography assay, latex lossis fluorescent microsphere immunochromatography, enzyme-linked immunosorbent assay (ELISA), thiab chemiluminescence assay.
03.Viral antigen detection
Antigen yog cov qauv ntawm tus kab mob uas tau lees paub los ntawm tib neeg lub cev uas ua rau lub cev tiv thaiv kab mob los tsim cov tshuaj tiv thaiv kom tshem tau tus kab mob los ntawm cov ntshav thiab cov ntaub so ntswg.Tus kab mob antigen muaj nyob rau ntawm tus kab mob tuaj yeem raug tsom thiab kuaj pom los ntawm kev siv immunoassay.Zoo li tus kab mob RNA, cov tshuaj tiv thaiv kab mob viral kuj tseem muaj nyob hauv cov kab mob ua pa ntawm cov neeg muaj tus kab mob thiab tuaj yeem siv los kuaj xyuas qhov mob hnyav ntawm tus kab mob COVID-19.Yog li ntawd, nws raug pom zoo kom sau cov kab mob ua pa sab saud xws li qaub ncaug, nasopharyngeal thiab oropharyngeal swabs, hnoos hnoos hnoos sib sib zog nqus, bronchoalveolar lavage kua (BALF) rau kev kuaj thawj zaug antigen.
Kev xaiv cov kev sim rau tus kabmob tshiab tshiab
Kev xaiv ib txoj kev sim muaj ntau yam, suav nrog kev teeb tsa kev kho mob, kev ntsuas kev tswj xyuas zoo, lub sijhawm hloov pauv, cov nqi kuaj, cov qauv sau cov qauv, cov neeg ua haujlwm hauv chaw kuaj mob, cov khoom siv thiab cov khoom yuav tsum tau ua.Kev kuaj pom ntawm nucleic acids lossis viral antigens yog muab cov pov thawj ncaj qha ntawm qhov muaj cov kab mob thiab lees paub qhov kev kuaj mob ntawm tus kab mob coronavirus tshiab.Txawm hais tias muaj ntau txoj hauv kev rau kev kuaj pom cov tshuaj tiv thaiv, lawv qhov kev tshawb nrhiav pom ntawm tus kabmob tshiab tshiab yog qhov kev xav tau qis dua li ntawm RT-PCR amplification.Kev kuaj tshuaj tiv thaiv kab mob yog kev tshawb nrhiav cov tshuaj tiv thaiv kab mob uas tsim tawm hauv tib neeg lub cev, uas yog lag luam nyob rau lub sijhawm thiab feem ntau tsis tuaj yeem siv rau kev tshawb pom ntxov thaum lub sijhawm mob kis tus kab mob.Qhov chaw kho mob rau kev kuaj xyuas daim ntawv thov tuaj yeem sib txawv, thiab cov chaw sau cov qauv kuj yuav txawv.Rau kev kuaj pom ntawm kis nucleic acids thiab antigens, qhov kev txiav txim siab yuav tsum tau sau rau hauv cov pa ua pa, hnoos qeev, hnoos qeev, lossis bronchoalvalvololle fluws (balf).Txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau tshuaj tiv thaiv kab mob, cov qog ntshav yuav tsum tau sau thiab tshuaj xyuas seb puas muaj cov tshuaj tiv thaiv kab mob tshwj xeeb (IgM / IgG).Txawm li cas los xij, cov txiaj ntsig ntawm cov tshuaj tiv thaiv kab mob thiab nucleic acid tuaj yeem sib ntxiv.Piv txwv li, thaum qhov kev ntsuam xyuas yog cov nucleic acid-tsis zoo, IgM-negative tab sis IgG-zoo, cov txiaj ntsig no qhia tau tias tus neeg mob tam sim no tsis muaj tus kab mob no, tab sis tau zoo los ntawm tus kab mob coronavirus tshiab.[2]
Qhov zoo thiab qhov tsis zoo ntawm kev kuaj mob coronavirus tshiab
Hauv Kev Tshawb Fawb thiab Kev Kho Mob rau Novel Coronavirus Pneumonia (Tshwj Sim Version7) (Tshaj tawm los ntawm National Health Commission & State Administration of Traditional Chinese Medicine thaum Lub Peb Hlis 3, 2020), kev sim nucleic acid yog siv los ua tus txheej txheem kub rau kev kuaj mob tshiab. Tus kab mob coronavirus, thaum kuaj tshuaj tiv thaiv kab mob kuj tseem suav tias yog ib txoj hauv kev pom zoo rau kev kuaj mob.
Pathogenic thiab serological tshawb pom
(1) Kev tshawb pom tus kab mob: Novel coronavirus nucleic acid tuaj yeem kuaj pom hauv nasopharyngeal swabs, hnoos qeev, qis ua pa tawm, ntshav, quav thiab lwm yam qauv siv RT-PCRand / lossis NGS txoj kev.Nws yog qhov tseeb dua yog tias cov qauv tau txais los ntawm cov kab mob ua pa qis (cov hnoos qeev lossis cov pa tawm tawm).Cov qauv yuav tsum raug xa mus kuaj sai li sai tau tom qab sau.
(2) Kev tshawb pom serological: NCP tus kab mob tshwj xeeb IgM tuaj yeem kuaj pom nyob ib puag ncig 3-5 hnub tom qab pib;IgG ncav cuag qhov titration tsawg kawg 4-fold nce thaum lub sij hawm convalescence piv nrog rau theem mob.
Txawm li cas los xij, kev xaiv cov kev sim ntsuas nyob ntawm thaj chaw thaj chaw, cov kev cai kho mob, thiab chaw kho mob.Hauv Teb Chaws Asmeskas, NIH tau tshaj tawm Cov Kab Mob Coronavirus 2019 (COVID-19) Cov Lus Qhia Txog Kev Kho Mob (Site Updated: Lub Plaub Hlis 21, 2020) thiab FDA tau tshaj tawm Txoj Cai rau Kev Ntsuam Xyuas Kab Mob Coronavirus-2019 thaum muaj xwm txheej ceev rau pej xeem noj qab haus huv (tso tawm rau lub Peb Hlis 16, 2020. ), nyob rau hauv uas kev soj ntsuam serological ntawm IgM / IgG cov tshuaj tiv thaiv tsuas yog xaiv raws li kev tshuaj ntsuam xyuas.
Nucleic Acid Detection Method
RT_PCR yog ib qho kev ntsuam xyuas nucleic acid uas muaj kev cuam tshuam loj heev uas tsim los xyuas seb puas muaj tus kab mob coronavirus tshiab RNA nyob hauv lub ntsws lossis lwm yam qauv.Qhov txiaj ntsig zoo ntawm PCR cov txiaj ntsig txhais tau hais tias muaj tus kabmob tshiab RNA nyob rau hauv cov qauv kom paub meej tias tus kabmob COVID-19.Cov txiaj ntsig tsis zoo PCR tsis tau txhais hais tias tsis muaj tus kab mob no vim tias nws tuaj yeem cuam tshuam los ntawm cov qauv tsis zoo lossis lub sijhawm muaj kab mob kis nyob rau theem zoo, thiab lwm yam.Txawm hais tias RT-PCR yog qhov kev sim siab heev, nws muaj ntau qhov tsis zoo.Kev xeem RT-PCR tuaj yeem ua haujlwm hnyav thiab siv sijhawm, nyob ntawm qhov zoo ntawm cov qauv.Qhov no tuaj yeem yog qhov nyuaj vim tias tus nqi ntawm tus kab mob RNA tsis tsuas yog sib txawv ntawm cov neeg mob sib txawv tab sis kuj tuaj yeem sib txawv hauv tib tus neeg mob nyob ntawm lub sijhawm cov ntsiab lus thaum cov qauv sau nrog rau cov theem kab mob lossis qhov pib ntawm cov tsos mob.Kev kuaj xyuas tus kabmob tshiab no yuav tsum muaj cov qauv zoo uas muaj cov kabmob RNA txaus txaus.
Qhov kev sim RT-PCR tuaj yeem muab cov txiaj ntsig tsis raug (tsis zoo tsis zoo) rau qee tus neeg mob uas muaj tus kab mob COVID-19.Raws li peb paub, cov chaw kis kab mob tseem ceeb ntawm tus kabmob tshiab no yog nyob ntawm lub ntsws thiab cov kab mob ua pa qis, xws li alveoli thiab bronchi.Yog li ntawd, cov hnoos qeev los ntawm hnoos sib sib zog nqus los yog cov kua dej bronchoalveolar lavage (BALF) suav tias muaj qhov siab tshaj plaws rau kev kuaj kab mob.Txawm li cas los xij, hauv kev kho mob, cov qauv feem ntau tau sau los ntawm cov kab mob ua pa sab saud los ntawm kev siv nasopharyngeal lossis oropharyngeal swabs.Kev sau cov qauv no tsis yog qhov tsis xis nyob rau cov neeg mob nkaus xwb tab sis kuj yuav tsum muaj cov neeg ua haujlwm tshwj xeeb.Txhawm rau ua kom tsis muaj kev cuam tshuam los yog yooj yim dua, qee zaum cov neeg mob yuav tau muab lub qhov ncauj qhov ncauj thiab tso cai rau lawv coj tus qauv ntawm lub plab mucosa lossis tus nplaig swabbing lawv tus kheej.Yog tias tsis muaj tus kab mob RNA txaus, RT-qPCR tuaj yeem xa rov qab qhov ntsuas tsis zoo-tsis zoo.Hauv Hubei xeev, Tuam Tshoj, RT-PCR rhiab heev nyob rau hauv thawj zaug kuaj tau tshaj tawm txog 30% -50%, nrog rau qhov nruab nrab ntawm 40%.Qhov siab ntawm qhov tsis tseeb-tsis zoo yog feem ntau tshwm sim los ntawm kev kuaj tsis txaus.
Tsis tas li ntawd, qhov kev xeem RT-PCR xav tau cov neeg ua haujlwm tau txais kev cob qhia los ua cov txheej txheem RNA rho tawm thiab PCR amplification txheej txheem.Nws tseem yuav tsum muaj kev tiv thaiv biosafety ntau dua, chav kuaj tshwj xeeb, thiab cov cuab yeej PCR tiag tiag.Hauv Suav teb, kev sim RT-PCR rau kev kuaj pom COVID-19 yuav tsum tau ua hauv biosafety qib 2 lub chaw soj nstuam (BSL-2), nrog rau kev tiv thaiv cov neeg ua haujlwm siv biosafety qib 3 (BSL-3).Raws li cov kev cai no, txij thaum pib lub Ib Hlis mus txog Lub Ob Hlis 2020, lub peev xwm ntawm Tuam Tshoj Wuhan's CDC lub chaw kuaj mob tsuas tuaj yeem kuaj tau ob peb puas kis nyob rau ib hnub.Feem ntau, qhov no yuav tsis muaj teeb meem thaum kuaj lwm yam kab mob sib kis.Txawm li cas los xij, thaum cuam tshuam nrog kev sib kis thoob ntiaj teb xws li COVID-19 uas muaj peev xwm ntau lab tus tib neeg raug kuaj, RT-PCR dhau los ua qhov teeb meem tseem ceeb vim nws yuav tsum muaj rau cov chaw kuaj mob tshwj xeeb lossis cov cuab yeej siv.Cov kev tsis zoo no yuav txwv tsis pub RT-PCR siv los ua cov cuab yeej siv tau zoo rau kev tshuaj ntsuam xyuas, thiab tseem tuaj yeem ua rau qeeb hauv cov ntawv ceeb toom ntawm kev sim.
Serological antibody nrhiav txoj kev
Nrog rau kev nce qib ntawm cov kab mob, tshwj xeeb tshaj yog nyob rau hauv nruab nrab thiab lig theem, cov tshuaj tiv thaiv kab mob yog siab heev.Ib txoj kev tshawb fawb hauv Wuhan Central South Tsev Kho Mob tau qhia tias qhov ntsuas tshuaj tiv thaiv kab mob tuaj yeem ncav cuag ntau dua 90% hauv lub lim tiam thib peb ntawm COVID-19.Tsis tas li, cov tshuaj tiv thaiv yog cov khoom lag luam ntawm tib neeg lub cev tiv thaiv kab mob tiv thaiv tus kabmob tshiab.Cov tshuaj tiv thaiv kab mob muaj ntau qhov zoo dua RT-PCR.Ua ntej, cov tshuaj tiv thaiv serological kuaj tau yooj yim thiab nrawm.Antibody lateral flow tests tuaj yeem siv rau qhov chaw saib xyuas kom xa cov txiaj ntsig hauv 15 feeb.Qhov thib ob, lub hom phiaj kuaj pom los ntawm kev kuaj serological yog cov tshuaj tiv thaiv kab mob, uas paub tias muaj kev ruaj khov dua li tus kab mob RNA.Thaum lub sij hawm sau, thauj, khaws cia thiab kuaj, cov qauv rau cov tshuaj tiv thaiv kab mob feem ntau ruaj khov dua li cov qauv rau RT-PCR.Thib peb, vim tias cov tshuaj tiv thaiv kab mob sib npaug sib npaug hauv cov ntshav ncig, muaj qhov piv txwv tsawg dua piv rau kev kuaj nucleic acid.Cov qauv ntim xav tau rau kev kuaj tshuaj tiv thaiv kab mob yog qhov me me.Piv txwv li, 10 microliter ntawm cov ntiv tes-prick ntshav yog txaus rau siv nyob rau hauv lub antibody lateral flow test.
Feem ntau, cov tshuaj tiv thaiv kab mob yog xaiv los ua ib qho cuab yeej ntxiv rau kev tshawb nrhiav nucleic acid txhawm rau txhim kho qhov kev kuaj pom tus kab mob tshiab coronavirus thaum lub sijhawm kawm kab mob.Thaum cov tshuaj tiv thaiv kab mob tau siv ua ke nrog kev sim nucleic acid, nws tuaj yeem ua rau muaj qhov tseeb ntawm qhov kev kuaj mob ntawm COVID19 los ntawm kev txo qis cov txiaj ntsig tsis tseeb thiab tsis tseeb-tsis zoo.Daim ntawv qhia kev ua haujlwm tam sim no tsis pom zoo siv ob hom kev xeem sib cais raws li hom kev tshawb nrhiav ywj pheej tab sis yuav tsum tau siv los ua ib hom ntawv sib xyaw.[2]
Daim duab 2:Kev txhais lus tseeb ntawm nucleic acid thiab cov tshuaj tiv thaiv kab mob rau kev kuaj pom tus kab mob coronavirus tshiab
Daim duab 3:Liming Bio-Products Co., Ltd. - Novel coronavirus IgM/IgG antibody dual ceev kuaj cov khoom (StrongStep®SARS-CoV-2 IgM/IgG Antibody Rapid Test, Latex Immunochromatography)
Daim duab 4:Liming Bio-Products Co., Ltd. - StrongStep®Novel Coronavirus (SARS-CoV-2) Multiplex Real-Time PCR kit (nrhiav peb genes, fluorescent probe method).
Nco tseg:Cov khoom siv PCR zoo heev, npaj rau siv no muaj nyob rau hauv hom lyophilized (txheej txheej txheem kom qhuav) rau kev cia ntev.Cov khoom siv tuaj yeem thauj thiab khaws cia hauv chav sov thiab ruaj khov rau ib xyoos.Txhua lub raj ntawm premix muaj tag nrho cov reagents xav tau rau PCR amplification, nrog rau Reverse-transcriptase, Taq polymerase, primers, probes, thiab dNTPs substrates.Cov neeg siv tau yooj yim reconstitute cov mix los ntawm kev ntxiv PCR-qib dej nrog rau lub template thiab ces load. mus rau PCR ntsuas los khiav lub amplification.
Hauv kev teb rau tus kabmob tshiab tus kabmob tshiab no, Liming Bio-Products Co., Ltd. tau ua haujlwm nrawm los tsim ob lub cuab yeej kuaj mob kom pab tau cov chaw kuaj mob thiab pej xeem kev noj qab haus huv kom kuaj pom tus kab mob COVID-19 sai.Cov khoom siv no yog qhov tsim nyog rau kev siv rau kev tshuaj ntsuam loj hauv cov tebchaws thiab thaj chaw uas tus kab mob coronavirus tshiab tau kis mus sai, thiab muab kev kuaj mob thiab kev pom zoo rau tus kab mob COVID-19.Cov khoom siv no tsuas yog siv rau hauv Pre-notified Emergency Use Authorization (PEUA).Kev ntsuas tsuas yog txwv rau cov chaw kuaj mob uas tau lees paub raws li cov cai ntawm lub tebchaws lossis cov cai hauv cheeb tsam.
Txoj kev tshawb nrhiav Antigen
1. Viral antigen detection yog cais nyob rau hauv tib qeb ntawm kev tshawb nrhiav ncaj qha raws li kev tshawb nrhiav nucleic acid.Cov kev tshawb nrhiav ncaj qha no nrhiav cov pov thawj ntawm cov kab mob kis hauv cov qauv thiab tuaj yeem siv rau kev kuaj pom tseeb.Txawm li cas los xij, kev txhim kho cov khoom siv tshuaj tiv thaiv antigen yuav tsum muaj cov tshuaj tiv thaiv kab mob monoclonal zoo uas muaj kev sib raug zoo thiab muaj kev nkag siab zoo uas muaj peev xwm lees paub thiab ntes cov kab mob pathogenic.Nws feem ntau yuav siv sijhawm ntau tshaj rau lub hlis los xaiv thiab ua kom zoo dua cov tshuaj tiv thaiv kab mob monoclonal haum rau siv hauv kev npaj cov khoom siv tshuaj tiv thaiv kab mob.
2. Tam sim no, cov tshuaj reagents rau kev kuaj pom tus kab mob tshiab tshiab tseem nyob hauv kev tshawb fawb thiab kev txhim kho theem.Yog li ntawd, tsis muaj cov khoom siv tshuaj tiv thaiv antigen tau raug kuaj xyuas thiab ua lag luam.Txawm hais tias yav dhau los tau tshaj tawm tias lub tuam txhab kuaj mob hauv Shenzhen tau tsim cov khoom siv tshuaj tiv thaiv antigen thiab kuaj hauv Spain, qhov kev soj ntsuam kev ntseeg tau thiab qhov tseeb tsis tuaj yeem raug lees paub vim muaj cov teeb meem zoo reagent.Txog niaj hnub no, NMPA (yav tas los Tuam Tshoj FDA) tseem tsis tau pom zoo cov khoom siv tshuaj tiv thaiv antigen rau kev kho mob tseem.Hauv kev xaus, ntau txoj kev tshawb nrhiav tau raug tsim.Txhua txoj kev muaj nws qhov zoo thiab kev txwv.Cov txiaj ntsig los ntawm ntau txoj hauv kev tuaj yeem siv los txheeb xyuas thiab ntxiv.
3. Kev tsim cov khoom siv kuaj COVID-19 zoo yog nyob ntawm kev ua kom zoo dua thaum tshawb fawb thiab tsim kho.Liming Bio-Product Co., Ltd.Cov khoom siv kuaj yuav tsum ua kom tau raws li kev tsim khoom nruj thiab cov qauv kev tswj xyuas kom ntseeg tau tias lawv muab cov qib siab tshaj plaws ntawm kev ua tau zoo thiab sib xws.Cov kws tshawb fawb ntawm Liming Bio-Product Co., Ltd. muaj ntau tshaj nees nkaum xyoo kev paub hauv kev tsim, kuaj, thiab ua kom zoo hauv cov khoom siv tshuaj ntsuam xyuas vitro kom ntseeg tau tias qib siab tshaj plaws ntawm kev ua tau zoo hauv kev txheeb xyuas qhov ntau.
Thaum lub sijhawm COVID-19 kis thoob qhov txhia chaw, tsoomfwv Suav tau ntsib kev xav tau loj heev rau cov ntaub ntawv tiv thaiv kabmob sib kis hauv thoob ntiaj teb hotspots.Thaum Lub Plaub Hlis 5, ntawm lub rooj sib tham xov xwm ntawm Lub Xeev Pawg Saib Xyuas Kev Tiv Thaiv Kev Tiv Thaiv thiab Kev Tswj Xyuas "Nruam Kev Tswj Xyuas Zoo ntawm Cov Khoom Siv Kho Mob thiab Kev Tswj Xyuas Kev Ua Lag Luam", Jiang Fan, tus thawj saib xyuas qib ntawm Ministry of Foreign Trade Department. ntawm Kev Lag Luam, tau hais tias, "Tom ntej no, peb yuav tsom mus rau peb txoj kev mob siab rau ob qho tib si, ua ntej, txhawm rau txhawm rau txhawm rau txhawb kev txhawb nqa ntawm ntau cov khoom siv kho mob uas xav tau los ntawm cov zej zog thoob ntiaj teb, thiab tseem, txhawm rau txhim kho kev tswj hwm, kev tswj hwm, thiab kev tswj hwm cov khoom. Peb yuav ua rau Tuam Tshoj txoj kev koom tes los koom ua ke teb rau kev sib kis thoob ntiaj teb thiab tsim kom muaj kev sib koom ua ke rau yav tom ntej rau noob neej.
Daim duab 5:Liming Bio-Products Co., Ltd. tus tshiab coronavirus reagent tau txais daim ntawv pov thawj EU CE sau npe
Daim ntawv pov thawj honorary
Houshenshan
Daim duab 6. Liming Bio-Products Co., Ltd. txhawb nqa Wuhan Vulcan (HouShenShan) Lub Tsev Kho Mob Roob los tiv thaiv COVID-19 kev sib kis thiab tau txais daim ntawv pov thawj qhuas ntawm Wuhan Red Cross.Wuhan Vulcan roob tsev kho mob yog lub tsev kho mob nto moo tshaj plaws hauv Suav teb uas tshwj xeeb hauv kev kho mob ntawm COVID-19 cov neeg mob hnyav.
Raws li tus kab mob tshiab coronavirus tseem kis mus thoob ntiaj teb, Nanjing Liming Bio-Products Co., Ltd. tab tom nce qib los txhawb thiab pab cov zej zog thoob ntiaj teb nrog peb cov thev naus laus zis tshiab los tawm tsam qhov kev hem thawj thoob ntiaj teb uas tsis tau muaj dua.Kev sim ceev ceev ntawm tus kab mob COVID-19 yog ib feem tseem ceeb ntawm kev daws qhov kev hem thawj no.Peb txuas ntxiv pab txhawb txoj hauv kev tseem ceeb los ntawm kev muab cov txheej txheem kuaj mob zoo rau hauv tes ntawm cov neeg ua haujlwm saib xyuas kev noj qab haus huv pem hauv ntej kom tib neeg tuaj yeem tau txais cov txiaj ntsig tseem ceeb uas lawv xav tau.Liming Bio-products Co., Ltd. txoj kev siv zog hauv kev sib ntaus sib tua tiv thaiv COVID-19 kis thoob qhov txhia chaw yog los pab txhawb peb cov thev naus laus zis, kev paub dhau los, thiab kev txawj ntse rau cov zej zog thoob ntiaj teb rau kev tsim kho lub ntiaj teb kev vam meej hauv zej zog.
Xovxwm Ntev ~ Scan thiab Ua Raws Li Peb
Email: sales@limingbio.com
Lub Vev Xaib: https://limingbio.com
Post lub sij hawm: May-01-2020
